Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.
Identifieur interne : 000570 ( Main/Exploration ); précédent : 000569; suivant : 000571Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.
Auteurs : P. Kranke [Allemagne] ; J P Thompson [Royaume-Uni] ; P L Dalby [États-Unis] ; L H Eberhart [Allemagne] ; E. Novikova [Russie] ; B M Johnson [États-Unis] ; S F Russ [États-Unis] ; R. Noble [États-Unis] ; R A Brigandi [États-Unis]Source :
- British journal of anaesthesia [ 1471-6771 ] ; 2015.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Antagonistes du récepteur de la neurokinine-1 (usage thérapeutique), Antiémétiques (usage thérapeutique), Femelle, Fluorobenzènes (usage thérapeutique), Humains, Jeune adulte, Mâle, Méthode en simple aveugle, Ondansétron (usage thérapeutique), Pipéridines (usage thérapeutique), Relation dose-effet des médicaments, Résultat thérapeutique, Sujet âgé, Vomissements et nausées postopératoires (traitement médicamenteux), Échec thérapeutique.
- MESH :
- traitement médicamenteux : Vomissements et nausées postopératoires.
- usage thérapeutique : Antagonistes du récepteur de la neurokinine-1, Antiémétiques, Fluorobenzènes, Ondansétron, Pipéridines.
- Adulte, Adulte d'âge moyen, Femelle, Humains, Jeune adulte, Mâle, Méthode en simple aveugle, Relation dose-effet des médicaments, Résultat thérapeutique, Sujet âgé, Échec thérapeutique.
English descriptors
- KwdEn :
- Adult, Aged, Antiemetics (therapeutic use), Dose-Response Relationship, Drug, Female, Fluorobenzenes (therapeutic use), Humans, Male, Middle Aged, Neurokinin-1 Receptor Antagonists (therapeutic use), Ondansetron (therapeutic use), Piperidines (therapeutic use), Postoperative Nausea and Vomiting (drug therapy), Single-Blind Method, Treatment Failure, Treatment Outcome, Young Adult.
- MESH :
- chemical , therapeutic use : Antiemetics, Fluorobenzenes, Neurokinin-1 Receptor Antagonists, Ondansetron, Piperidines.
- drug therapy : Postoperative Nausea and Vomiting.
- Adult, Aged, Dose-Response Relationship, Drug, Female, Humans, Male, Middle Aged, Single-Blind Method, Treatment Failure, Treatment Outcome, Young Adult.
Abstract
Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was performed to evaluate the efficacy and safety of vestipitant, compared with ondansetron for the treatment of breakthrough PONV in patients who had already received prophylactic ondansetron before surgery.
DOI: 10.1093/bja/aeu376
PubMed: 25488303
Affiliations:
- Allemagne, Royaume-Uni, Russie, États-Unis
- Bavière, Caroline du Nord, District de Basse-Franconie, District de Giessen, District fédéral central, Hesse (Land), Pennsylvanie
- Marbourg, Moscou, Wurtzbourg
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000439
- to stream PubMed, to step Curation: 000439
- to stream PubMed, to step Checkpoint: 000439
- to stream Ncbi, to step Merge: 004350
- to stream Ncbi, to step Curation: 004350
- to stream Ncbi, to step Checkpoint: 004350
- to stream Main, to step Merge: 000570
- to stream Main, to step Curation: 000570
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.</title><author><name sortKey="Kranke, P" sort="Kranke, P" uniqKey="Kranke P" first="P" last="Kranke">P. Kranke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany kranke_p@ukw.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Thompson, J P" sort="Thompson, J P" uniqKey="Thompson J" first="J P" last="Thompson">J P Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthetics, Leicester Royal Infirmary, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Anaesthetics, Leicester Royal Infirmary, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Dalby, P L" sort="Dalby, P L" uniqKey="Dalby P" first="P L" last="Dalby">P L Dalby</name><affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesia, Magee-Women's Hospital, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anesthesia, Magee-Women's Hospital, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Eberhart, L H" sort="Eberhart, L H" uniqKey="Eberhart L" first="L H" last="Eberhart">L H Eberhart</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anaesthesiology and Critical Care Medicine, Philipps-University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology and Critical Care Medicine, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Novikova, E" sort="Novikova, E" uniqKey="Novikova E" first="E" last="Novikova">E. Novikova</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecology, Moscow Herzen Oncology Institute, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Gynecology, Moscow Herzen Oncology Institute, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Johnson, B M" sort="Johnson, B M" uniqKey="Johnson B" first="B M" last="Johnson">B M Johnson</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Research Triangle Park, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Russ, S F" sort="Russ, S F" uniqKey="Russ S" first="S F" last="Russ">S F Russ</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Research Triangle Park, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Noble, R" sort="Noble, R" uniqKey="Noble R" first="R" last="Noble">R. Noble</name><affiliation wicri:level="2"><nlm:affiliation>King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Brigandi, R A" sort="Brigandi, R A" uniqKey="Brigandi R" first="R A" last="Brigandi">R A Brigandi</name><affiliation wicri:level="2"><nlm:affiliation>King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25488303</idno><idno type="pmid">25488303</idno><idno type="doi">10.1093/bja/aeu376</idno><idno type="wicri:Area/PubMed/Corpus">000439</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000439</idno><idno type="wicri:Area/PubMed/Curation">000439</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000439</idno><idno type="wicri:Area/PubMed/Checkpoint">000439</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000439</idno><idno type="wicri:Area/Ncbi/Merge">004350</idno><idno type="wicri:Area/Ncbi/Curation">004350</idno><idno type="wicri:Area/Ncbi/Checkpoint">004350</idno><idno type="wicri:Area/Main/Merge">000570</idno><idno type="wicri:Area/Main/Curation">000570</idno><idno type="wicri:Area/Main/Exploration">000570</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.</title><author><name sortKey="Kranke, P" sort="Kranke, P" uniqKey="Kranke P" first="P" last="Kranke">P. Kranke</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg, Germany kranke_p@ukw.de.</nlm:affiliation><country wicri:rule="url">Allemagne</country><wicri:regionArea>Department of Anaesthesia and Critical Care, University Hospitals of Würzburg, Oberdürrbacher Str. 6, D-97080 Würzburg</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Basse-Franconie</region><settlement type="city">Wurtzbourg</settlement></placeName></affiliation></author><author><name sortKey="Thompson, J P" sort="Thompson, J P" uniqKey="Thompson J" first="J P" last="Thompson">J P Thompson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthetics, Leicester Royal Infirmary, Leicester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Anaesthetics, Leicester Royal Infirmary, Leicester</wicri:regionArea><wicri:noRegion>Leicester</wicri:noRegion></affiliation></author><author><name sortKey="Dalby, P L" sort="Dalby, P L" uniqKey="Dalby P" first="P L" last="Dalby">P L Dalby</name><affiliation wicri:level="2"><nlm:affiliation>Department of Anesthesia, Magee-Women's Hospital, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Anesthesia, Magee-Women's Hospital, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Eberhart, L H" sort="Eberhart, L H" uniqKey="Eberhart L" first="L H" last="Eberhart">L H Eberhart</name><affiliation wicri:level="3"><nlm:affiliation>Department of Anaesthesiology and Critical Care Medicine, Philipps-University, Marburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology and Critical Care Medicine, Philipps-University, Marburg</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Giessen</region><settlement type="city">Marbourg</settlement></placeName></affiliation></author><author><name sortKey="Novikova, E" sort="Novikova, E" uniqKey="Novikova E" first="E" last="Novikova">E. Novikova</name><affiliation wicri:level="3"><nlm:affiliation>Department of Gynecology, Moscow Herzen Oncology Institute, Moscow, Russian Federation.</nlm:affiliation><country xml:lang="fr">Russie</country><wicri:regionArea>Department of Gynecology, Moscow Herzen Oncology Institute, Moscow</wicri:regionArea><placeName><settlement type="city">Moscou</settlement><region>District fédéral central</region></placeName></affiliation></author><author><name sortKey="Johnson, B M" sort="Johnson, B M" uniqKey="Johnson B" first="B M" last="Johnson">B M Johnson</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Research Triangle Park, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Russ, S F" sort="Russ, S F" uniqKey="Russ S" first="S F" last="Russ">S F Russ</name><affiliation wicri:level="2"><nlm:affiliation>GlaxoSmithKline, Research Triangle Park, NC, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>GlaxoSmithKline, Research Triangle Park, NC</wicri:regionArea><placeName><region type="state">Caroline du Nord</region></placeName></affiliation></author><author><name sortKey="Noble, R" sort="Noble, R" uniqKey="Noble R" first="R" last="Noble">R. Noble</name><affiliation wicri:level="2"><nlm:affiliation>King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Brigandi, R A" sort="Brigandi, R A" uniqKey="Brigandi R" first="R A" last="Brigandi">R A Brigandi</name><affiliation wicri:level="2"><nlm:affiliation>King of Prussia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>King of Prussia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author></analytic><series><title level="j">British journal of anaesthesia</title><idno type="eISSN">1471-6771</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antiemetics (therapeutic use)</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Fluorobenzenes (therapeutic use)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neurokinin-1 Receptor Antagonists (therapeutic use)</term><term>Ondansetron (therapeutic use)</term><term>Piperidines (therapeutic use)</term><term>Postoperative Nausea and Vomiting (drug therapy)</term><term>Single-Blind Method</term><term>Treatment Failure</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Antagonistes du récepteur de la neurokinine-1 (usage thérapeutique)</term><term>Antiémétiques (usage thérapeutique)</term><term>Femelle</term><term>Fluorobenzènes (usage thérapeutique)</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en simple aveugle</term><term>Ondansétron (usage thérapeutique)</term><term>Pipéridines (usage thérapeutique)</term><term>Relation dose-effet des médicaments</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Vomissements et nausées postopératoires (traitement médicamenteux)</term><term>Échec thérapeutique</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiemetics</term><term>Fluorobenzenes</term><term>Neurokinin-1 Receptor Antagonists</term><term>Ondansetron</term><term>Piperidines</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Postoperative Nausea and Vomiting</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Vomissements et nausées postopératoires</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antagonistes du récepteur de la neurokinine-1</term><term>Antiémétiques</term><term>Fluorobenzènes</term><term>Ondansétron</term><term>Pipéridines</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dose-Response Relationship, Drug</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Single-Blind Method</term><term>Treatment Failure</term><term>Treatment Outcome</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Mâle</term><term>Méthode en simple aveugle</term><term>Relation dose-effet des médicaments</term><term>Résultat thérapeutique</term><term>Sujet âgé</term><term>Échec thérapeutique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postoperative nausea and vomiting (PONV) is common; ondansetron is often used as prophylaxis or for breakthrough episodes. Vestipitant is a neurokinin 1 (NK-1) receptor antagonist that is effective for prophylaxis, but its efficacy for treating established PONV is unknown. This study was performed to evaluate the efficacy and safety of vestipitant, compared with ondansetron for the treatment of breakthrough PONV in patients who had already received prophylactic ondansetron before surgery.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>Russie</li><li>États-Unis</li></country><region><li>Bavière</li><li>Caroline du Nord</li><li>District de Basse-Franconie</li><li>District de Giessen</li><li>District fédéral central</li><li>Hesse (Land)</li><li>Pennsylvanie</li></region><settlement><li>Marbourg</li><li>Moscou</li><li>Wurtzbourg</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Kranke, P" sort="Kranke, P" uniqKey="Kranke P" first="P" last="Kranke">P. Kranke</name></region><name sortKey="Eberhart, L H" sort="Eberhart, L H" uniqKey="Eberhart L" first="L H" last="Eberhart">L H Eberhart</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Thompson, J P" sort="Thompson, J P" uniqKey="Thompson J" first="J P" last="Thompson">J P Thompson</name></noRegion></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Dalby, P L" sort="Dalby, P L" uniqKey="Dalby P" first="P L" last="Dalby">P L Dalby</name></region><name sortKey="Brigandi, R A" sort="Brigandi, R A" uniqKey="Brigandi R" first="R A" last="Brigandi">R A Brigandi</name><name sortKey="Johnson, B M" sort="Johnson, B M" uniqKey="Johnson B" first="B M" last="Johnson">B M Johnson</name><name sortKey="Noble, R" sort="Noble, R" uniqKey="Noble R" first="R" last="Noble">R. Noble</name><name sortKey="Russ, S F" sort="Russ, S F" uniqKey="Russ S" first="S F" last="Russ">S F Russ</name></country><country name="Russie"><region name="District fédéral central"><name sortKey="Novikova, E" sort="Novikova, E" uniqKey="Novikova E" first="E" last="Novikova">E. Novikova</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Amérique/explor/PittsburghV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000570 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000570 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Amérique
|area= PittsburghV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:25488303
|texte= Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:25488303" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PittsburghV1
| This area was generated with Dilib version V0.6.38. |  |